| Bioactivity | GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM)[1]. |
| CAS | 2644044-43-7 |
| Formula | C23H15NO3 |
| Molar Mass | 353.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pamarthy, et al. "Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells." Drug Development Research 84.5 (2023): 861-887. |
GPX4-IN-13
CAS: 2644044-43-7 F: C23H15NO3 W: 353.37
GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and
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