| Bioactivity | GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1]. |
| Name | GPR84 antagonist 2 |
| CAS | 2244269-74-5 |
| Formula | C28H16Cl2NaO4PS2 |
| Molar Mass | 605.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006. |
GPR84 antagonist 2
CAS: 2244269-74-5 F: C28H16Cl2NaO4PS2 W: 605.42
GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antago
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This product is for research use only, not for human use. We do not sell to patients.