GPR40 agonist 6_product_DataBase

CAS: 1798751-25-3 F: C20H19NO4 W: 337.37

GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM[1].

Target

EC50: 0.058 μM (GPR40)

Invitro

GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 µM[1].ADME profile for GPR40 agonist 6 (Compound 7a)[1]

Name

GPR40 agonist 6

CAS

1798751-25-3

Formula

C20H19NO4

Molar Mass

337.37

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Zahanich I, et al. Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3105-11.

PeptideDB

GPR40 agonist 6

CAS: 1798751-25-3 F: C20H19NO4 W: 337.37