| Bioactivity | GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1]. | ||||||||||||
| Target | GPR35 | ||||||||||||
| Name | GPR35 agonist 4 | ||||||||||||
| CAS | 871085-49-3 | ||||||||||||
| Formula | C12H9NO5S | ||||||||||||
| Molar Mass | 279.27 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Jenkins L, et al. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2. Br J Pharmacol. 2011 Feb;162(3):733-48. |
GPR35 agonist 4
CAS: 871085-49-3 F: C12H9NO5S W: 279.27
GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human
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