| Bioactivity | GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1]. | ||||||||||||
| In Vivo | GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1]. | ||||||||||||
| Name | GPR30 agonist-1 | ||||||||||||
| CAS | 415919-74-3 | ||||||||||||
| Formula | C19H17BrFNO | ||||||||||||
| Molar Mass | 374.25 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Brad R S Broughton, et al. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61. |