| Bioactivity | GPR120 Agonist 5 (compound 12) is an agonist targeting GPR120 (EC50=1.2 μM). GPR120 Agonist 5 promotes the release of glucagon-like 1 (GLP-1) by binding to the GPR120 receptor, which in turn binds to its receptors on pancreatic beta cells, increasing insulin secretion and thereby lowering blood sugar levels. GPR120 Agonist 5 also helps reduce chronic low-grade inflammation, which plays an important role in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. GPR120 Agonist 5 can be used to investigate the mechanism of action of GPR120 in metabolic and inflammatory diseases[1][2]. |
| CAS | 1079821-35-4 |
| Formula | C23H24N2O3 |
| Molar Mass | 376.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Suzuki T, et al. Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists[J]. Journal of medicinal chemistry, 2008, 51(23): 7640-7644. [2]. Shimpukade B, et al. Discovery of a potent and selective GPR120 agonist[J]. Journal of medicinal chemistry, 2012, 55(9): 4511-4515. |
GPR120 Agonist 5
CAS: 1079821-35-4 F: C23H24N2O3 W: 376.45
GPR120 Agonist 5 (compound 12) is an agonist targeting GPR120 (EC50=1.2 μM). GPR120 Agonist 5 promotes the release of g
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