GPR120 Agonist 4_product_DataBase

Bioactivity	GPR120 Agonist 4 (example 1) is a GPR120 agonist，with the EC50 values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus[1].
Invitro	GPR120 Agonist 4 (example 1) (0.012-25 μM, 90 min) 在 CHO-K1 GPR120 β-Arrestin 细胞中可通过 β-抑制蛋白的募集来激活 GPR120[1]。GPR120 Agonist 4 (0.012-25 μM, 90 min) 在过表达人 GPR120 的 HEK293 细胞中促进钙离子的释放，验证了 GPR120 Agonist 4 对 GPR120 的激活效果[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GPR120 Agonist 4 相关抗体:
In Vivo	GPR120 Agonist 4 (example 1) (0.2/0.3/1/3/10 mg/kg, i.p., 15/30/45/60/90 min) 剂量依赖性地促进食用高脂肪小鼠模型的葡萄糖水平下降[1]。GPR120 Agonist 4 (1/3/10 mg/kg, i.p., 15/30/45/60/90 min) 剂量依赖性地抑制饥饿小鼠模型的葡萄糖水平上升[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1628641-89-3
Formula	C21H15ClF5NO3
Molar Mass	459.79
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. SUI, Zhihua, et al. Bicyclic pyrrole derivatives useful as agonists of gpr120. WO2015134038. 2014-03-07

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