| Bioactivity | GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide agonist P12 acetateis a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 acetate can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 acetate mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 acetate can be used in the study of developmental disorders and cancers related to GPR110[1]. | ||||||
| Sequence | Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Phe-Val-Pro | ||||||
| Shortening | TSFSILMSPFVP | ||||||
| Formula | C65H100N12O19S.xC2H4O2 | ||||||
| Molar Mass | 1325.57 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Stoveken H M, et al. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist[J]. Proceedings of the National Academy of Sciences, 2015, 112(19): 6194-6199. |
GPR110 peptide agonist P12 acetate
CAS: F: C65H100N12O19S.xC2H4O2 W: 1325.57 (free base)
GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide ag
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