| Bioactivity | GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD). |
| Invitro | GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1]. GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1]. GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1]. Apoptosis Analysis[1] Cell Line: |
| Name | GPR |
| CAS | 47295-77-2 |
| Shortening | GPR |
| Formula | C13H24N6O4 |
| Molar Mass | 328.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |