| Bioactivity | GP130-IN-1 (compound 49) is a potent GP130 inhibitor with significant in vitro antitumor activity and higher selectivity than Bazedoxifene (HY-A0031). GP130-IN-1 induces ultrastructural changes in cells, causing cell cycle arrest in the G0/G1 phase in a time-dependent manner and triggering apoptosis and autophagy. GP130-IN-1 can be used in the study of triple-negative breast cancer[1]. |
| CAS | 2955243-69-1 |
| Formula | C21H10F5NO3 |
| Molar Mass | 419.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu P, et al. Structurally diverse design and synthesis of novel 2-phenylindole amide derivatives with anti-canine breast cancer activity[J]. Bioorganic Chemistry, 2024: 107788. |
GP130-IN-1
CAS: 2955243-69-1 F: C21H10F5NO3 W: 419.30
GP130-IN-1 (compound 49) is a potent GP130 inhibitor with significant in vitro antitumor activity and higher selectivity
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