| Bioactivity | GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. | ||||||||||||
| Target | IC50: 62 nM (aryl hydrocarbon receptor) | ||||||||||||
| Invitro | GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | GNF351 | ||||||||||||
| CAS | 1227634-69-6 | ||||||||||||
| Formula | C24H25N7 | ||||||||||||
| Molar Mass | 411.50 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. van den Bogaard EH, et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328. |