| Bioactivity | GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively. |
| CAS | 1196546-33-4 |
| Formula | C31H30FN7O |
| Molar Mass | 535.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Selectively targeting tropomyosin receptor kinase a (TRKA) via PROTACs |
GNF-8625
CAS: 1196546-33-4 F: C31H30FN7O W: 535.61
GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-
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