| Bioactivity | GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma[1]. | ||||||||||||
| Invitro | GNE-9822 (compound 28) 抑制 PLCγ 的磷酸化，IC50 值为 55 nM[1]。 | ||||||||||||
| In Vivo | GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) 在小鼠和大鼠中观察到良好的生物利用度和半衰期[1]。 Animal Model: | ||||||||||||
| Name | GNE-9822 | ||||||||||||
| CAS | 1557232-32-2 | ||||||||||||
| Formula | C24H32N6O | ||||||||||||
| Molar Mass | 420.55 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Burch JD, et, al. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J Med Chem. 2014 Jul 10;57(13):5714-27. |