| Bioactivity | GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1]. | ||||||||||||
| Target | TEAD. | ||||||||||||
| Name | GNE-7883 | ||||||||||||
| CAS | 2648450-42-2 | ||||||||||||
| Formula | C28H29FN6O2 | ||||||||||||
| Molar Mass | 500.57 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828. |
GNE-7883
CAS: 2648450-42-2 F: C28H29FN6O2 W: 500.57
GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhib
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