| Bioactivity | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. | ||||||||||||
| Invitro | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1]. | ||||||||||||
| Name | GNE 5729 | ||||||||||||
| CAS | 2026635-66-3 | ||||||||||||
| Formula | C17H10Cl2F3N5O | ||||||||||||
| Molar Mass | 428.20 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89. |
GNE 5729
CAS: 2026635-66-3 F: C17H10Cl2F3N5O W: 428.20
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.