| Bioactivity | GNE-555 is a selective, metabolically stable mTOR inhibitor (Ki=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research[1][2]. |
| Name | GNE-555 |
| CAS | 1428902-71-9 |
| Formula | C26H34N6O3 |
| Molar Mass | 478.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Apr 11;56(7):3090-101. [2]. Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802. |