| Bioactivity | GNE-0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1]. | ||||||||||||
| Target | EC50: 21 nM (GluN2A), 7.4 μM (GluN2C), 6.2 μM (GluN2D) | ||||||||||||
| Invitro | GNE-0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1]. | ||||||||||||
| Name | GNE-0723 | ||||||||||||
| CAS | 1883518-31-7 | ||||||||||||
| Formula | C16H8ClF6N5OS | ||||||||||||
| Molar Mass | 467.78 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89. |
GNE-0723
CAS: 1883518-31-7 F: C16H8ClF6N5OS W: 467.78
GNE-0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM
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