| Bioactivity | GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research[1]. |
| Invitro | GMQ (1 mM) 在 pH 7.4 的条件下，产生持续向内电流在 CHO 细胞中[1]。GMQ 在高浓度时阻断 ASIC 孔隙，对 ASIC1a，ASIC1b 和 ASIC3 的 IC50 值分别为 3.24，1.52 和 6.74 mM[1]。 |
| Name | GMQ |
| CAS | 5361-15-9 |
| Formula | C10H12ClN5 |
| Molar Mass | 237.69 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Alijevic O, Kellenberger S. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem. 2012 Oct 19;287(43):36059-70. |