| Bioactivity | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1]. | ||||||||||||
| Name | GMB-475 | ||||||||||||
| CAS | 2490599-18-1 | ||||||||||||
| Formula | C43H46F3N7O7S | ||||||||||||
| Molar Mass | 861.93 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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GMB-475
CAS: 2490599-18-1 F: C43H46F3N7O7S W: 861.93
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-47
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