| Bioactivity | GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration[1]. |
| Invitro | GM-60186 (50-500nM；72 小时) 可有效抑制结直肠癌 (CRC) 细胞的增殖[1]。GM-60186 (500nM；24-48 小时) 可有效抑制结直肠癌的迁移[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GM-60186 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | GM-60186（10-20 mg/kg；腹腔注射；每日；持续 20 天）可显著减小异种移植小鼠模型中的肿瘤大小和重量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C30H33FN2O4 |
| Molar Mass | 504.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jeong-Yun Lee, et al. Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling. Biomed Pharmacother. 2024 Oct:179:117428. |