GLUT1/EGFR-IN-1

CAS: 2393787-80-7 F: C44H32N4O5 W: 696.75

GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of GLUT1 and EGFR. GLUT1/EGFR-IN-1 can simultaneously act on the EGFR

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Bioactivity	GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of GLUT1 and EGFR. GLUT1/EGFR-IN-1 can simultaneously act on the EGFR tyrosine kinase ATP-binding site and inhibit GLUT1-mediated energy metabolism, resulting in reductions in ATP, MMP, intra-cellular lactic acid, and EGFR nuclear transfer. GLUT1/EGFR-IN-1 can be used for nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC) research[1].
Invitro	GLUT1/EGFR-IN-1 (compound H) 在 CNE1 和 MDA-MB231 细胞中表现出优异的抗肿瘤活性，IC50 值低于 3 µmol/L，但在 CNE2 细胞中活性不明显[1]。GLUT1/EGFR-IN-1 (0-4 μM，48 小时)抑制 CNE1 和 MDA-MB231 细胞中 EGFR 和 p-EGFR 的表达[1]。GLUT1/EGFR-IN-1 (0-4 μM，48 小时)诱导 CNE1 和 MDA-MB231 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GLUT1/EGFR-IN-1 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	GLUT1/EGFR-IN-1 (compound H) (4-8 mg/kg，腹腔注射，2周)抑制裸鼠模型中 MDA-MB231 移植肿瘤细胞的生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2393787-80-7
Formula	C44H32N4O5
Molar Mass	696.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang C, et al. Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma. Eur J Pharm Sci. 2024 Jul 1;198:106789.