| Bioactivity | GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1]. | ||||||||||||
| Target | Cystic fibrosis transmembrane conductance regulator | ||||||||||||
| Invitro | GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1]. | ||||||||||||
| Name | GLPG2451 | ||||||||||||
| CAS | 2055015-61-5 | ||||||||||||
| Formula | C16H16F3N3O5S | ||||||||||||
| Molar Mass | 419.38 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221. |
GLPG2451
CAS: 2055015-61-5 F: C16H16F3N3O5S W: 419.38
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low
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