GLPG-3221

CAS: 2222264-64-2 F: C30H37F3N2O6 W: 578.62

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC

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Bioactivity	GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].
In Vivo	GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively[1].GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1]. Animal Model:
Name	GLPG-3221
CAS	2222264-64-2
Formula	C30H37F3N2O6
Molar Mass	578.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Scanio MJC, et al.Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548.