| Bioactivity | GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1]. | ||||||||||||
| Target | IC50: 650 nM (GLP-1R). | ||||||||||||
| Name | GLP-1R Antagonist 1 | ||||||||||||
| CAS | 488097-06-9 | ||||||||||||
| Formula | C16H11ClF6N4O2 | ||||||||||||
| Molar Mass | 440.73 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrim |
GLP-1R Antagonist 1
CAS: 488097-06-9 F: C16H11ClF6N4O2 W: 440.73
GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like pep
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