| Bioactivity | GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects[1]. | ||||||
| Invitro | Different from DPP-IV, NEP, which cleaves GLP-1(7-36)amide or GLP-1(9-36)amide to generate GLP-1(28-36)amide, is widely distributed in endothelial cells, vascular smooth muscle cells, cardiac cells and renal epithelial cells[1]. GLP-1(28-36)amide (100 nM) treatment on hepatocytes for 24 hours directly modulates mitochondrial oxidative metabolism, such as gluconeogenesis in mitochondria of hepatocytes[1]. The plasma half-life of GLP-1(28-36)amide is longer in human hepatocytes (t1/2 = 24 min) than that in mouse hepatocytes (t1/2 = 13 min)[1]. | ||||||
| Name | GLP-1(28-36)amide | ||||||
| CAS | 1225021-13-5 | ||||||
| Sequence | Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 | ||||||
| Shortening | FIAWLVKGR-NH2 | ||||||
| Formula | C54H85N15O9 | ||||||
| Molar Mass | 1088.35 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
GLP-1(28-36)amide
CAS: 1225021-13-5 F: C54H85N15O9 W: 1088.35
GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutr
Data collection：peptidedb@qq.com
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