| Bioactivity | GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice[1]. |
| Target | HDAC inhibitor；https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01422 (Compd 21b);新品上线，张雨新分子推荐20231017 |
| Name | GK718 |
| Formula | C26H30Cl2N4O3 |
| Molar Mass | 517.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gerokonstantis DT, et al. N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. J Med Chem. 2023 Oct 26;66(20):14357-14376. |