| Bioactivity | GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1]. |
| In Vivo | GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。 |
| Name | GJ103 |
| CAS | 1459687-89-8 |
| Formula | C16H14N4O3S |
| Molar Mass | 342.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. |