| Bioactivity | GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations[1]. |
| Invitro | GJ103 (10-30 μM; 4 days) sodium 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。GJ103 sodium 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。 |
| Name | GJ103 sodium |
| CAS | 1459687-96-7 |
| Formula | C16H13N4NaO3S |
| Molar Mass | 364.35 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. |
GJ103 sodium
CAS: 1459687-96-7 F: C16H13N4NaO3S W: 364.35
GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potentia
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