| Bioactivity | GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma[1]. |
| Invitro | GIC-20 (1 μM, 48 h) 抑制 HT1080 纤维肉瘤细胞的增殖和迁移，表现出细胞毒性，IC50 为 1.6 μM[1]。GIC-20 (0.5-4 μM, 24 h) 通过诱导细胞内脂质过氧化物和 ROS 积累，或通过降解 GPX4 诱导铁死亡 (ferroptosis)[1]。GIC-20 (0-1 μM, 24 h) 抑制耐药 MIA-PaCa-2-AMG510R 细胞的细胞活力，增强 MIA-PaCa-2-AMG510R 细胞对 AMG510 的敏感性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GIC-20 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | GIC-20 (20-40 mg/kg，腹腔注射，每天一次共 19 天) 在 HT1080 异种移植 BALB/c 小鼠中表现出抗肿瘤活性，且对主要器官没有明显毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2942242-60-4 |
| Formula | C38H37ClN4O5S |
| Molar Mass | 697.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma F, et al., ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. Eur J Med Chem. 2024 Apr 15;270:116387. |