| Bioactivity | GEA 3162, oxatriazol derivative, is a NO-releasing compound. GEA 3162 can be used for the research of Inflammation diseases[1]. |
| Invitro | GEA 3162（1-100 μM）抑制 Ca 离子载体 A23187 诱导的 LTB4 和 β-葡萄糖醛酸酶释放、趋化肽 FMLP 诱导的趋化作用和调理酵母聚糖触发的化学发光，剂量依赖性抑制人 PMNs[1]。 GEA 3162 (0-1 mM) 以剂量依赖性方式抑制人体 PMN 释放 LTB4[1]。GEA 3162（0-1 mM）以剂量依赖性方式抑制 A23187 激活的 PMN 释放 β-葡萄糖醛酸酶[1]。GEA 3162 (0-1 mM) 是 FMLP 诱导的人类 PMN 趋化运动的有效抑制剂，IC50 值为 6 μM[1]。GEA 3162 在较低的药物浓度下更快地提高循环 GMP 水平[1]。 |
| Name | GEA 3162 |
| CAS | 144576-10-3 |
| Formula | C7H4Cl2N4O |
| Molar Mass | 231.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Moilanen E, et al. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br J Pharmacol. 1993;109(3):852-858. |