| Bioactivity | GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC50 of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC50 of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 (HY-130592)-induced systemic allergic reaction model[1]. |
| Target | IC50: 9.42 μM (MRGPRX2) |
| CAS | 2883669-12-1 |
| Formula | C28H22N2O5 |
| Molar Mass | 466.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kumar M, et al., Mrgprx2 antagonist for the treatment of pseudo allergic reactions. US20220401435 |