| Bioactivity | GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively. |
| Target | IC50: 35 nM (hTRβ), 200 nM (hTRα). |
| Invitro | GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[3]. |
| Name | GC 14 |
| CAS | 447415-34-1 |
| Formula | C26H27NO6 |
| Molar Mass | 449.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7. [2]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [3]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20. |