| Bioactivity | GABAA receptor modular-3 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modular-3 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modular-3 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression[1]. |
| Target | EC50: 56 nM (GABAA receptor α1β2γ2); 10 nM (GABAA receptor α4β3δ) |
| CAS | 3021554-08-2 |
| Formula | C28H36F2N4O3 |
| Molar Mass | 514.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma M, et al., Synthesis and evaluation of neuroactive steroids with novel pharmacophore at C-21 let identify a compound with advantageous PK profile and higher EC50 and Emax as PAM on GABAA receptor. Eur J Med Chem. 2024 Jun 22;276:116602. |
GABAA receptor modular-3
CAS: 3021554-08-2 F: C28H36F2N4O3 W: 514.61
GABAA receptor modular-3 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50
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