| Bioactivity | GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1]. |
| Invitro | GABAA receptor agent 5 (compound 018) shows antagonist activity with IC50s of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, 0.051 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1]. |
| Name | GABAA receptor agent 5 |
| CAS | 1808389-92-5 |
| Formula | C21H25N3O2S |
| Molar Mass | 383.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bavo F,et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64(24):17795-17812. |
GABAA receptor agent 5
CAS: 1808389-92-5 F: C21H25N3O2S W: 383.51
GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 s
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