| Bioactivity | G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2]. | ||||||
| Invitro | G7-18NATE (10 μM, 24 h) 抑制 MDA-MB-468 细胞迁移[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> G7-18NATE TFA 相关抗体: | ||||||
| Sequence | cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-) | ||||||
| Shortening | cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-) | ||||||
| Formula | C67H80N14O19S.xC2HF3O2 | ||||||
| Molar Mass | 1417.50 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. |
G7-18NATE TFA
CAS: F: C67H80N14O19S.xC2HF3O2 W: 1417.50 (free base)
G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (Kd =
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