| Bioactivity | G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1]. | ||||||||||||
| Target | IC50: 10.2 nM (h-cGAS) | ||||||||||||
| Invitro | G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages[1].G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages[1].G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells[1]. RT-PCR[1] Cell Line: | ||||||||||||
| Name | G150 | ||||||||||||
| CAS | 2369751-30-2 | ||||||||||||
| Formula | C18H16Cl2N4O2 | ||||||||||||
| Molar Mass | 391.25 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261. |
G150
CAS: 2369751-30-2 F: C18H16Cl2N4O2 W: 391.25
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDN
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This product is for research use only, not for human use. We do not sell to patients.