G0-C14_product_DataBase

Bioactivity	G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery[1][2].
Invitro	G0-C14 exhibits strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%[1].Preparation of NPs[1]:1.Dissolve PolyHCPT and DSPE-PEG3K in DMF to form a homogenous solution at a concentration of 5 mg/mL.2.Prepare a mixture of 1 nmol of siRNA (0.1 nmol/µL aqueous solution) and G0-C14 (5 mg/mL in DMF) in different N/P molar ratios. Mixed them with the polyHCPT and DSPE-PEG3K solution.3.Under vigorous stirring (1000 rpm), add the mixture dropwise to 5 mL of deionized water. 4.Transferr the formed NP dispersion to an ultrafiltration device.5.Ccentrifug at room temperature (2800 rpm×8 min) to remove the organic solvent and free compounds.
Name	G0-C14
CAS	1510653-27-6
Formula	C106H216N10O10
Molar Mass	1790.91
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li S, et al. Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy. Biomaterials. 2020 Mar;234:119760. [2]. Chen Q, et al. Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy. J Control Release. 2020 Jul 10;323:179-190.

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