| Bioactivity | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[1][2]. |
| Invitro | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100 nM[1].Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1 µM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50 nM[1].Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 µM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function[1]. |
| Name | Fz7-21 |
| CAS | 2247635-23-8 |
| Shortening | Ac-LPSDDLEFWCHVMY-NH2 |
| Formula | C83H114N18O23S2 |
| Molar Mass | 1796.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Fz7-21
CAS: 2247635-23-8 F: C83H114N18O23S2 W: 1796.05
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass
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