| Bioactivity | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2]. | ||||||
| Invitro | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA (0-100 μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC50 value of 100 nM[1].Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA (1 µM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 value of 50 nM[1].Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA (200 µM; 48 h; LGR5–GFP+ stem cells) disrupts LGR5+ stem cell function[1]. | ||||||
| Name | Fz7-21 TFA | ||||||
| Shortening | Ac-LPSDDLEFWCHVMY-NH2 | ||||||
| Formula | C85H115N18F3O25S2 | ||||||
| Molar Mass | 1910.07 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |