Fuzapladib_product_DataBase

Bioactivity	Fuzapladib (IS-741) is a potent phospholipase A2 inhibitor. Fuzapladib can block the adhesion of inflammatory cells to microvascular endothelial cells, inhibit the infiltration of neutrophils into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects[1].
Invitro	Fuzapladib(IS-741)(1 μM, 3 h)在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附[1]。
In Vivo	Fuzapladib(IS-741)(p.o., 50 mg/kg, 7 days) 显着降低了大鼠回肠中的髓过氧化物酶 (MPO) 活性和粘膜 IL-8 水平，减少了多形核细胞和 Mac-1 阳性细胞向发炎病灶的浸润，有效减轻了三硝基苯磺酸(TNBS)诱导的大鼠回肠炎[2]。
Name	Fuzapladib
CAS	141283-87-6
Formula	C15H20F3N3O3S
Molar Mass	379.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. H Shikama, et al. Effect of IS-741 on Cell Adhesion between Human Umbilical Vein Endothelial Cells and HL-60 Cells. [2]. Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9.

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