Fuzapladib sodium_product_DataBase

Bioactivity

Fuzapladib sodium (IS-741 sodium) is a potent and orally active phospholipase A2 inhibitor. Fuzapladib sodium can block the adhesion of inflammatory cells to microvascular endothelial cells, inhibits the infiltration of neutrophils into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects[1][2].

Invitro

Fuzapladib sodium (IS-741 sodium)(1 μM, 3 h) 在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附[1]。

In Vivo

Fuzapladib sodium (IS-741 sodium) (p.o., 50 mg/kg, 7 days) 抑制中性粒细胞浸润炎性病变，对减轻大鼠TNBS回肠炎有效[2]。 Animal Model:

Name

Fuzapladib sodium

CAS

141284-73-3

Formula

C15H20F3N3NaO3S

Molar Mass

402.39

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. [2]. Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9.

PeptideDB

Fuzapladib sodium

CAS: 141284-73-3 F: C15H20F3N3NaO3S W: 402.39