| Bioactivity | Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2]. |
| Name | Funalenone |
| CAS | 259728-61-5 |
| Formula | C15H12O6 |
| Molar Mass | 288.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100. [2]. Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314(2):243-52. [3]. Kazuro Shiomi, et al. Fungal phenalenones inhibit HIV-1 integrase. J Antibiot (Tokyo). 2005 Jan;58(1):65-8. [4]. Inokoshi J, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100. |