Fumonisin B1-13C34_product_DataBase

Bioactivity	Fumonisin B1-13C34 is the 13C labeled Fumonisin B1 (HY-N6719)[1]. Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[2][3].
Target	Sphingosine N-acyltransferase
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Fumonisin B1 改变猴肾细胞基因表达和信号转导通路[2]。Fumonisin B1 增加鞘脂代谢的初始破坏和鞘氨醇在 LLC-PK1 肾细胞中的积累，导致大鼠星形胶质细胞凋亡型 DNA 损伤[2]。
Name	Fumonisin B1-13C34
CAS	1217458-62-2
Formula	13C34H59NO15
Molar Mass	755.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

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