Fulvestrant-3-boronic acid_product_DataBase

Bioactivity	Fulvestrant-3-boronic acid is an orally active ERα inhibitor, which binds to ERα competitively (IC50 = 4.1 nM) and effectively degrades ERα in breast cancer cells[1].
Invitro	Fulvestrant-3-boronic acid (1-27 nM, 5 d) 剂量依赖性地显著下调 T47D 和 T47D/PKCα 细胞中的 ERα 蛋白[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Fulvestrant-3-boronic acid 相关抗体:
In Vivo	Fulvestrant-3-boronic acid (8.3 mg/kg, 口服) 显示出的 T /2 为 23.5 小时，Cmax 为 169.8 ng/mL, AUC 为 2547.1 ng•h/mL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1853279-29-4
Formula	C32H48BF5O4S
Molar Mass	634.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu J, et al. Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD). J Med Chem. 2016 Sep 8;59(17):8134-40.

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