| Bioactivity | Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression[1][2]. | ||||||||||||
| Invitro | Fudosteine (50, 100, 200 mg/kg) decreases the LPS-induced p-ERK1/2 and p-p38 MAPK levels in the rat lungs. The TNF-α-induced increase in MUC5AC mRNA expression is inhibited by pretreatment with 1 mM Fudosteine[1]. | ||||||||||||
| Name | Fudosteine | ||||||||||||
| CAS | 13189-98-5 | ||||||||||||
| Formula | C6H13NO3S | ||||||||||||
| Molar Mass | 179.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Rhee CK, et al. Effect of fudosteine on mucin production. Eur Respir J. 2008;32(5):1195-1202. [2]. Takahashi K, et al. Nihon Yakurigaku Zasshi. 2000;116(6):371-378. |