| Bioactivity | Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1]. |
| Invitro | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3].Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. Cell Viability Assay[1] Cell Line: |
| Name | Fucosterol |
| CAS | 17605-67-3 |
| Formula | C29H48O |
| Molar Mass | 412.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |