| Bioactivity | FtsZ-IN-6 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-6 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-6 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-6 shows low hemolytic activity and cytotoxicity to mammalian cells[1]. |
| Invitro | FtsZ-IN-6 (compound B6) 抑制测试的革兰氏阳性菌，包括耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC=0.098 μg/mL)、枯草芽孢杆菌 (MIC=0.098 μg/mL) 和肺炎链球菌 (MIC=0.049 μg/mL)[1]。FtsZ-IN-6 (1-4× MIC；0-24 h) 抑制 MRSA 细菌生长。并且 FtsZ-IN-6 (4× MIC; 4 h) 扰乱了 MRSA ATCC43300 的细胞表面，使其表面出现明显的皱纹和丝状结构[1]。FtsZ-IN-6 (4 μg/mL; 10 min; 25 ℃) 促进 FtsZ 聚合并 (0.02-0.64 μg/mL; 30 min) 剂量依赖性地抑制 FtsZ 的 GTPase 活性[1]。FtsZ-IN-6 (12.5 μg/mL; 1 h; 37 ℃) 对人红细胞 RAW264.7 细胞的溶血活性可忽略不计[1]。 Cell Viability Assay[1] Cell Line: |
| Name | FtsZ-IN-6 |
| Formula | C28H22BrN3O2 |
| Molar Mass | 512.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qiu H, et al. Design and synthesis of fascaplysin derivatives as inhibitors of FtsZ with potent antibacterial activity and mechanistic study. Eur J Med Chem. 2023 Jun 5;254:115348. |