| Bioactivity | Fradafiban (BIBU-52) hydrochloride is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. |
| Target | Kd: 148 nM (human platelet GP IIb/IIIa complex) |
| Invitro | Fradafiban hydrochloride 是精氨酸-甘氨酸-天冬氨酸识别序列的非肽模拟物。 Fradafiban hydrochloride 以高亲和力和选择性结合人血小板 GP IIb/IIIa 复合物，并在体外有效抑制人血小板聚集。 Fradafiban hydrochloride 可逆地结合人血小板 GP IIb/IIIa 复合物，Kd 值为 148 nM[1]。 |
| In Vivo | Fradafiban hydrochloride 仅具有非常有限的口服活性，这可能是由于其高极性，因此口服后吸收较差[1]。 |
| Name | Fradafiban hydrochloride |
| Formula | C20H22ClN3O4 |
| Molar Mass | 403.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8. |
Fradafiban hydrochloride
CAS: F: C20H22ClN3O4 W: 403.86
Fradafiban (BIBU-52) hydrochloride is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human p
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