Bioactivity | Fosmetpantotenate is a phosphopantothenic acid (PPA) prodrug designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to treat pantothenate kinase-associated neurodegeneration. |
Name | Fosmetpantotenate |
CAS | 1858268-66-2 |
Formula | C20H31N2O9P |
Molar Mass | 474.44 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Elbaum D, Beconi MG, Monteagudo E, et al. Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models. PLoS One. 2018;13(3):e0192028. Pu [2]. Klopstock T, et al. The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated n |