Fosfenopril_product_DataBase

Bioactivity

Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes[1][2].

Invitro

Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS[1].Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS[1].Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression[1]. Western Blot Analysis[1] Cell Line:

In Vivo

Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs[3]. Animal Model:

Name

Fosfenopril

CAS

95399-71-6

Formula

C23H34NO5P

Molar Mass

435.49

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Yang S, et al. Fosinoprilat alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes. Cell Immunol. 2013 Jul-Aug;284(1-2):182-6. [2]. DeForrest JM, et al. Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: in vitro and preclinical in vivo pharmacology. J Cardiovasc Pharmacol. 1989 Nov;14(5):730-6. [3]. DeForrest JM, et al. Blood pressure lowering and renal hemodynamic effects of fosinopril in conscious animal models. J Cardiovasc Pharmacol. 1990 Jul;16(1):139-46.

PeptideDB

Fosfenopril

CAS: 95399-71-6 F: C23H34NO5P W: 435.49